Anticoagulant Heparan Sulfate Mediates Antithrombin Amelioration of Leukocyte-Endothelial Interactions in Sepsis.

Abstract Antithrombin (AT) exhibits anti-inflammatory properties that reduce mortality in sepsis models. We examined the effects of AT on leukocyte-endothelial interactions in sepsis by using intravital microscopy to measure leukocyte rolling and firm adhesion in post-capillary venules of the cremaster muscle in live mice. Human AT (0.25U g−1 i.v. of Thrombate III, Bayer Corporation) or vehicle was infused prior to …