Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical Trial

Abstract

IMPORTANCE: Although millions of transfusions are given annually worldwide, the effect of red blood cell (RBC) unit storage duration on oxygen delivery is uncertain. OBJECTIVE: To determine if longer-storage RBC units are not inferior to shorter-storage RBC units for tissue oxygenation as measured by reduction in blood lactate levels and improvement in cerebral tissue oxygen saturation among children with severe anemia.

Authors

Dhabangi A; Ainomugisha B; Cserti-Gazdewich C; Ddungu H; Kyeyune D; Musisi E; Opoka R; Stowell CP; Dzik WH

Journal

JAMA: The Journal of the American Medical Association, Vol. 314, No. 23, pp. 1–10

Publisher

American Medical Association (AMA)

Publication Date

December 15, 2015

DOI

10.1001/jama.2015.13977

ISSN

0098-7484

Associated Experts

Henry Ddungu

Assistant Clinical Professor (Adjunct), Faculty of Health Sciences

Visit profile

Labels