Journal article
Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a Sheep model
Abstract
There has been interest in developing novel biological treatments to repair focal cartilage defects. We have developed a method of forming biphasic constructs ("osteochondral"-type plug) in vitro consisting of cartilaginous tissue, formed on and anchored to the intended articulation surface of a porous ceramic substrate. The purpose of this study was to evaluate the biochemical and biomechanical properties and morphology of in vitro-formed …
Authors
Kandel RA; Grynpas M; Pilliar R; Lee J; Wang J; Waldman S; Zalzal P; Hurtig M; Team C-BOST
Journal
Biomaterials, Vol. 27, No. 22, pp. 4120–4131
Publisher
Elsevier
Publication Date
August 2006
DOI
10.1016/j.biomaterials.2006.03.005
ISSN
0142-9612