Bacterial stimulation of endogenous hydrogen sulfide synthesis: a novel mechanism for resolution and repair in the colon

Hydrogen sulfide (H 2 S) is an important signaling molecule throughout the gastrointestinal (GI) tract. Colonic H 2 S synthesis is markedly increased during experimental colitis in rats, and contributes to the resolution of inflammation and healing of ulcers. The triggers responsible for this up‐regulation of colonic H 2 S synthesis are unclear. Therefore, we tested whether bacterial signals at the epithelial surface may be important stimuli …