Journal article
The Vagus Nerve: A Tonic Inhibitory Influence Associated With Inflammatory Bowel Disease in a Murine Model
Abstract
BACKGROUND & AIMS: The recently proposed Inflammatory Reflex describes an interaction between the vagus nerve and peripheral macrophages, resulting in attenuation of proinflammatory cytokine release in response to systemic exposure to bacterial endotoxin. The purpose of this study was to determine whether a similar vagus/macrophage axis modulates the inflammatory responses in the colon in mice.
METHODS: We assessed the Disease Activity Index …
Authors
Ghia JE; Blennerhassett P; Kumar–Ondiveeran H; Verdu EF; Collins SM
Journal
Gastroenterology, Vol. 131, No. 4, pp. 1122–1130
Publisher
Elsevier
Publication Date
10 2006
DOI
10.1053/j.gastro.2006.08.016
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnticoagulantsAppetite DepressantsDextran SulfateDinitrofluorobenzeneDisease Models, AnimalEatingGanglionic BlockersGanglionic StimulantsHexamethoniumInflammatory Bowel DiseasesMacrophage Colony-Stimulating FactorMacrophages, PeritonealMaleMiceMice, Inbred C57BLMice, Mutant StrainsNeural InhibitionNicotinePylorusSincalideVagotomyVagus Nerve