Journal article
The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues
Abstract
BACKGROUND & AIMS: Copolymers of hydroxyethyl methacrylate and styrene sulfonate complex with isolated gliadin (the toxic fraction of gluten) and prevent damage to the intestinal barrier in HLA-HCD4/DQ8 mice. We studied the activity toward gluten and hordein digestion and biologic effects of poly(hydroxyethyl methacrylate-co-styrene sulfonate (P(HEMA-co-SS)). We also investigated the effect of gliadin complex formation in intestinal biopsy …
Authors
Pinier M; Fuhrmann G; Galipeau HJ; Rivard N; Murray JA; David CS; Drasarova H; Tuckova L; Leroux J; Verdu EF
Journal
Gastroenterology, Vol. 142, No. 2, pp. 316–325.e12
Publisher
Elsevier
Publication Date
February 2012
DOI
10.1053/j.gastro.2011.10.038
ISSN
0016-5085