Within-Batch and Batch-to-Batch Inferential-Adaptive Control of Semibatch Reactors: A Partial Least Squares Approach

An inferential control strategy that combines within-batch information from process variable trajectories and information from prior batches to control multivariate product quality properties in semibatch reactors is presented. The approach extends mid-course correction (MCC) strategies by including batch-to-batch information in the controllers and an adaptive partial least squares (PLS) approach to update the models from batch to batch. As …