Journal article
Modeling and Optimization of a Tablet Manufacturing Line
Abstract
This paper investigates an approach to modeling and optimizing an industrial tablet manufacturing line for different API and excipient formulations. Multi-block partial lease square (PLS) models are built from historical data on a given class of drug products. The data blocks consisted of data on the mass fractions of API and 11 excipients used in the different formulations, the roller compaction process variables, the tablet press settings and …
Authors
Liu Z; Bruwer M-J; MacGregor JF; Rathore SSS; Reed DE; Champagne MJ
Journal
Journal of Pharmaceutical Innovation, Vol. 6, No. 3,
Publisher
Springer Nature
Publication Date
September 2011
DOI
10.1007/s12247-011-9112-8
ISSN
1872-5120