Effects of Gabapentin on Anxiety Induced by Simulated Public Speaking Academic Article uri icon

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  • The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated. Thirty-two normal male volunteers (aged 17-30 years) had their anxiety and mood evaluated by self-scales [Visual Analogue Mood Scale (VAMS) and Profile of Mood State (POMS)] during the SPS procedure. Physiological measures (heart rate and blood pressure) were taken. Treatment with gabapentin at 800 mg attenuated the anxiety of subjects that had a decrease on the VAMS item calm-excite. In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin.


  • Quevedo, Joao
  • Barichello, Tatiana
  • Izquierdo, Ivan
  • Vianna, Monica RM
  • de-Paris, Fernanda
  • Busnello, Joao V
  • Kapczinski, Flavio
  • Sant'Anna, Marcia K

publication date

  • June 2003