Journal article
Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania
Abstract
Some studies suggest that mitochondrial dysfunction may be related to the pathophysiology of bipolar disorder. In this work, we evaluated the activity of citrate synthase in rats, and the effects of the treatment with mood stabilizers (lithium and valproate) on the enzyme activity. In the first experiment (reversal treatment), amphetamine or saline were administered to rats for 14 days, and between day 8 and 14, rats were treated with either …
Authors
Corrêa C; Amboni G; Assis LC; Martins MR; Kapczinski F; Streck EL; Quevedo J
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 31, No. 4, pp. 887–891
Publisher
Elsevier
Publication Date
May 2007
DOI
10.1016/j.pnpbp.2007.02.005
ISSN
0278-5846