Journal article
Sensitization and cross-sensitization after chronic treatment with methylphenidate in adolescent Wistar rats
Abstract
An increasing debate exists about the potential of early exposure to methylphenidate to increase the risk for drug abuse. In addition, little is known about the neurobiological effects of early exposure to methylphenidate. This study was designed to investigate whether chronic treatment with methylphenidate induces behavioral sensitization to subsequent methylphenidate and D-amphetamine challenge in adolescent Wistar rats. Young Wistar rats …
Authors
Valvassori SS; Frey BN; Martins MR; Réus GZ; Schimidtz F; Inácio CG; Kapczinski F; Quevedo J
Journal
Behavioural Pharmacology, Vol. 18, No. 3, pp. 205–212
Publisher
Wolters Kluwer
Publication Date
May 2007
DOI
10.1097/fbp.0b013e328153daf5
ISSN
0955-8810