Journal article
A gastrin-releasing peptide receptor antagonist blocks d-amphetamine-induced hyperlocomotion and increases hippocampal NGF and BDNF levels in rats
Abstract
The gastrin-releasing peptide receptor (GRPR) has emerged as a novel molecular target in neurological and psychiatric disorders, and previous animal studies suggest that GRPR antagonists might display cognitive-enhancing and antipsychotic properties. Hyperlocomotion produced by administration of D-amphetamine (D-AMPH) to rats has been put forward as a model of the manic phase of bipolar disorder (BD). In the present study, we examined the …
Authors
Kauer-Sant’Anna M; Andreazza AC; Valvassori SS; Martins MR; Barbosa LM; Schwartsmann G; Roesler R; Quevedo J; Kapczinski F
Journal
Peptides, Vol. 28, No. 7, pp. 1447–1452
Publisher
Elsevier
Publication Date
July 2007
DOI
10.1016/j.peptides.2007.06.010
ISSN
0196-9781