Journal article
Brain creatine kinase activity in an animal model of mania
Abstract
There is evidence pointing to dysfunction at the mitochondrial level as an important target for the understanding of the pathophysiology of bipolar disorder (BD). We assessed creatine kinase (CK) activity in rats submitted to an animal model of mania which included the use of lithium and valproate. In the acute treatment, amphetamine (AMPH) or saline was administered to rats for 14 days, and between day 8 and 14, rats were treated with either …
Authors
Streck EL; Amboni G; Scaini G; Di-Pietro PB; Rezin GT; Valvassori SS; Luz G; Kapczinski F; Quevedo J
Journal
Life Sciences, Vol. 82, No. 7-8, pp. 424–429
Publisher
Elsevier
Publication Date
2 2008
DOI
10.1016/j.lfs.2007.11.026
ISSN
0024-3205