Hyperglycaemia and mortality of diabetic patients with candidaemia

AbstractAims To determine whether the degree of hyperglycaemia has an impact on in‐hospital mortality in diabetic patients with candidaemia.Methods A retrospective cohort study of 87 diabetic patients with candidaemia admitted between June 1995 and June 2003 was carried out at two medical centres. Patients were stratified into two groups: those with moderate hyperglycaemia (7 days post‐candidaemia mean blood glucose < 13.9 mmol/l) and those with severe hyperglycaemia (7 days post‐candidaemia mean blood glucose ≥ 13.9 mmol/l). A stepwise logistic regression analysis was performed to determine whether the degree of hyperglycaemia was a significant predictor of mortality.Results During the follow‐up period from admission till discharge, 34 (39.1%) patients had died. Nine (69.2%) of 13 patients with severe hyperglycaemia have died while 25 (33.8%) of 74 patients with moderate hyperglycaemia have died. Multivariate analysis identified three independent determinants of death; Apache II score ≥ 23 [OR 8.1, 95% CI (2.6, 25.3), P = 0.0003], mean blood glucose levels 7 days post‐candidaemia ≥ 13.9 mmol/l [OR 6.8, 95% CI (1.2, 38.2), P = 0.03], and mechanical ventilation [OR 6.5, 95% CI (2.21), P = 0.03].Conclusion Severe hyperglycaemia is an important marker of increased mortality among hospitalized diabetic patients with candidaemia.

Hyperglycaemia and mortality of diabetic patients with candidaemia Journal Articles