Setting the record straight on TIDE: a lost opportunity for patients with diabetes

Much has been written regarding the recently discontinued Thiazolidinedione Intervention with Vitamin D Evaluation (TIDE) trial (ClinicalTrials.gov NCT00879970; Diabetologia 55: 36–45) and a variety of opinions have been advanced regarding its purpose, context and design (N Engl J Med 397: 959–964). As such, we deemed it appropriate to clarify TIDE’s objectives, research questions and design and the clinical equipoise regarding its research questions.