Journal article
PTHrP Induces Autocrine/Paracrine Proliferation of Bone Tumor Cells through Inhibition of Apoptosis
Abstract
Giant Cell Tumor of Bone (GCT) is an aggressive skeletal tumor characterized by local bone destruction, high recurrence rates and metastatic potential. Previous work in our lab has shown that the neoplastic cell of GCT is a proliferating pre-osteoblastic stromal cell in which the transcription factor Runx2 plays a role in regulating protein expression. One of the proteins expressed by these cells is parathyroid hormone-related protein (PTHrP). …
Authors
Mak IWY; Cowan RW; Turcotte RE; Singh G; Ghert M
Journal
PLOS ONE, Vol. 6, No. 5,
Publisher
Public Library of Science (PLoS)
Publication Date
2011
DOI
10.1371/journal.pone.0019975
ISSN
1932-6203