Journal article
Cobblestone Lissencephaly in Schinzel-Giedion Syndrome
Abstract
The brain of a 5-year-old boy with Schinzel-Giedion syndrome displayed a cobblestone appearance of orbital and lateral aspects of frontal lobes due to widespread glioneuronal meningeal heterotopia. Meningeal heterotopia consisted of scattered neurons, neurofilament positive axons, and myelinated fibers accompanied by striking astrocytic gliosis. The underlying cortex showed gaps in the pial basal lamina, distorted neuronal layering, and focal …
Authors
Lach B; Arredondo J
Journal
Journal of Child Neurology, Vol. 28, No. 2, pp. 259–263
Publisher
SAGE Publications
Publication Date
2 2013
DOI
10.1177/0883073812441250
ISSN
0883-0738