Journal article
Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer
Abstract
Telomerase reactivation is a hallmark of human carcinogenesis. Increased telomerase activity may result from gene amplification and/or overexpression. This study evaluates the prognostic value of hTERT gene amplification and mRNA overexpression in 144 resectable non-small-cell lung cancer (NSCLC) specimens. The hTERT gene copy number was assessed by quantitative polymerase chain reaction (qPCR) on laser-capture microdissected tumour cells of 81 …
Authors
Zhu C-Q; Cutz J-C; Liu N; Lau D; Shepherd FA; Squire JA; Tsao M-S
Journal
British Journal of Cancer, Vol. 94, No. 10, pp. 1452–1459
Publisher
Springer Nature
Publication Date
5 2006
DOI
10.1038/sj.bjc.6603110
ISSN
0007-0920
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Non-Small-Cell LungDNA, NeoplasmDNA-Binding ProteinsDisease ProgressionFemaleGene AmplificationGene Expression Regulation, NeoplasticHumansIn Situ Hybridization, FluorescenceLung NeoplasmsMaleMiddle AgedPrognosisRNA, MessengerReverse Transcriptase Polymerase Chain ReactionTelomerase