Journal article
Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam
Abstract
Objective and designThe objective of this study was to determine the ability of meloxicam prophylaxis and therapy to blunt the effect of complete Freund’s adjuvant (CFA) induced monoarthritis.Materials and methodsFirst the validity of this animal model was established by examining joint changes at multiple levels after injecting CFA into the tibio-tarsal joint. Next, meloxicam (5 mg/kg) or vehicle was administered on days 0–7 (prophylactic) and …
Authors
Hashmi JA; Yashpal K; Holdsworth DW; Henry JL
Journal
Inflammation Research, Vol. 59, No. 8, pp. 667–678
Publisher
Springer Nature
Publication Date
August 2010
DOI
10.1007/s00011-010-0179-3
ISSN
1023-3830