Journal article
In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats
Abstract
To examine the specific roles of group I metabotropic glutamate receptors (mGluRs) in nociceptive processing, we examined the effects of intrathecal (i.t.) treatment with antibodies raised against the C-terminals of mGluR1 and mGluR5 in various rat pain models. The effects of anti-mGluR1 IgG and anti-mGluR5 IgG were assessed in a model of persistent pain induced by intrathecal administration of the mGluR1/5 agonist DHPG, as well as in models of …
Authors
Fundytus ME; Fisher K; Dray A; Henry JL; Coderre TJ
Journal
Neuroreport, Vol. 9, No. 4, pp. 731–735
Publisher
Wolters Kluwer
Publication Date
March 1998
DOI
10.1097/00001756-199803090-00031
ISSN
0959-4965