Journal article
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver
Abstract
Elevation of plasma homocysteine levels has been recognized as an independent risk factor for the development of cardiovascular disease, a major complication of diabetes. Plasma homocysteine reflects a balance between its synthesis via S-adenosyl-L-methionine-dependent methylation reactions and its removal through the transmethylation and the transsulfuration pathways. Betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5) is one of the …
Authors
Ratnam S; Wijekoon EP; Hall B; Garrow TA; Brosnan ME; Brosnan JT
Journal
AJP Endocrinology and Metabolism, Vol. 290, No. 5, pp. e933–e939
Publisher
American Physiological Society
Publication Date
May 2006
DOI
10.1152/ajpendo.00498.2005
ISSN
0193-1849
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBetaine-Homocysteine S-MethyltransferaseCell Line, TumorCholine DehydrogenaseDiabetes Mellitus, ExperimentalGene ExpressionGlucocorticoidsInsulinLiverMaleRNA, MessengerRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionS-AdenosylhomocysteineS-AdenosylmethionineTranscription, GeneticTriamcinolone