Journal article
Role of the sodium pump in pacemaker generation in dog colonic smooth muscle.
Abstract
1. The role of the Na+ pump in the generation of slow wave activity in circular muscle of the dog colon was investigated using a partitioned 'Abe-Tomita' type chamber for voltage control. 2. Blockade of the Na+ pump by omission of extracellular K+, by ouabain, or the combination of 0 mM-Na+ and ouabain, depolarized the membrane up to approximately -40 mV and abolished the slow wave activity. Repolarization back to the control membrane potential …
Authors
Barajas-López C; Chow E; Hertog AD; Huizinga JD
Journal
The Journal of Physiology, Vol. 416, No. 1, pp. 369–383
Publisher
Wiley
Publication Date
September 1989
DOI
10.1113/jphysiol.1989.sp017766
ISSN
0022-3751