Journal article
Volume-activated chloride currents in interstitial cells of Cajal
Abstract
Interstitial cells of Cajal (ICC) undergo marked morphological changes on contraction of the musculature, making it essential to understand properties of mechanosensitive ion channels. The whole cell patch-clamp technique was used to identify and to characterize volume-activated Cl- currents in ICC cultured through the explant technique. Hypotonic solutions (approximately 210 mosM) activated an outwardly rectifying current, which reversed near …
Authors
Park SJ; Mckay CM; Zhu Y; Huizinga JD
Journal
AJP Gastrointestinal and Liver Physiology, Vol. 289, No. 5, pp. g791–g797
Publisher
American Physiological Society
Publication Date
11 2005
DOI
10.1152/ajpgi.00050.2005
ISSN
0193-1857