Journal article
Pharmacokinetics of Ximelagatran and Relationship to Clinical Response in Acute Deep Vein Thrombosis
Abstract
OBJECTIVE: Our objective was to characterize the pharmacokinetics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, and the relationship between melagatran exposure and clinical outcome in patients with acute deep vein thrombosis.
METHODS: A population pharmacokinetic analysis was performed on samples from patients with deep vein thrombosis participating in a randomized dose-finding study (THRombin Inhibitor in …
Authors
Cullberg M; Eriksson UG; Wåhlander K; Eriksson H; Schulman S; Karlsson MO
Journal
Clinical Pharmacology & Therapeutics, Vol. 77, No. 4, pp. 279–290
Publisher
Wiley
Publication Date
April 2005
DOI
10.1016/j.clpt.2004.11.001
ISSN
0009-9236