Conference
Safety, tolerability and pharmacokinetics of escalating doses of NXY-059 in healthy young and elderly subjects*
Abstract
OBJECTIVE: NXY-059 is a novel, free-radical trapping, neuroprotectant that reduces infarct size and preserves brain function in animal models of acute ischaemic stroke. This study evaluated the safety, tolerability and pharmacokinetics of NXY-059 in the unbound steady-state plasma concentration (Cu(ss)) exposure range of 50-300 micromol/L in healthy young and elderly subjects.
RESEARCH DESIGN AND METHODS: The primary objective of this …
Authors
Wemer J; Cheng Y-F; Nilsson D; Reinholdsson I; Fransson B; Vallén KL; Nyman L; Eriksson C; Björck S; Schulman S
Volume
22
Pagination
pp. 1813-1823
Publisher
Taylor & Francis
Publication Date
September 1, 2006
DOI
10.1185/030079906x121075
Conference proceedings
Current Medical Research and Opinion
Issue
9
ISSN
0300-7995