Journal article
Dysregulation of HOX11 by Chromosome Translocations in T-cell Acute Lymphoblastic Leukemia: A Paradigm for Homeobox Gene Involvement in Human Cancer
Abstract
The translocation t(10;14)(q24;q11) is observed in the course of routine cancer cytogenetic studies in 5-10% of patients with T-cell acute lymphoblastic leukemia (ALL). Recent molecular dissections of t(10;14) translocations support the hypothesis that these relatively gross chromosomal mutations represent key genetic steps in neoplastic transformation. The genes consistently involved are the T-cell receptor (TCR) delta-chain gene in 14q11 and …
Authors
Lichty BD; Ackland-Snow J; Noble L; Kamel-Reid S; Dube ID
Journal
Leukemia & Lymphoma, Vol. 16, No. 3-4, pp. 209–215
Publisher
Taylor & Francis
Publication Date
January 1995
DOI
10.3109/10428199509049759
ISSN
1042-8194