Journal article
Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis
Abstract
RATIONALE: Recent findings suggesting transforming growth factor (TGF)-β1 activation by mechanical stimuli in vitro raised the question of whether this phenomenon was relevant in vivo in the context of pulmonary fibrosis.
OBJECTIVES: To explore the effect of mechanical stress on TGF-β1 activation and its signaling pathway in rat and human fibrotic lung tissue using a novel ex vivo model.
Authors
Froese AR; Shimbori C; Bellaye P-S; Inman M; Obex S; Fatima S; Jenkins G; Gauldie J; Ask K; Kolb M
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 194, No. 1, pp. 84–96
Publisher
American Thoracic Society
Publication Date
July 1, 2016
DOI
10.1164/rccm.201508-1638oc
ISSN
1073-449X