The risks of PPI therapy

PPIs are one of the most commonly prescribed drugs worldwide. However, it has been suggested that PPIs are associated with an increased risk of pneumonia, bone fractures and enteric infections, and that they interact with clopidogrel. In this Review, Paul Moayyedi and Grigorios Leontiadis detail how the evidence supporting these associations is limited, but suggest that PPIs are only given to patients for whom these drugs have been proven beneficial.