Journal article
Angiogenesis is required for stress fracture healing in rats
Abstract
Although angiogenesis and osteogenesis are critically linked, the importance of angiogenesis for stress fracture healing is unknown. In this study, mechanical loading was used to create a non-displaced stress fracture in the adult rat forelimb. Fumagillin, an anti-angiogenic agent, was used as the water soluble analogue TNP-470 (25mg/kg) as well as incorporated into lipid-encapsulated α(v)β(3) integrin targeted nanoparticles (0.25mg/kg). In the …
Authors
Tomlinson RE; McKenzie JA; Schmieder AH; Wohl GR; Lanza GM; Silva MJ
Journal
Bone, Vol. 52, No. 1, pp. 212–219
Publisher
Elsevier
Publication Date
1 2013
DOI
10.1016/j.bone.2012.09.035
ISSN
8756-3282