Predictive value of metastatic cervical lymph node ratio in papillary thyroid carcinoma recurrence Journal Articles uri icon

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  • AbstractBackgroundThe purpose of this study was to determine whether the proportion of metastatic cervical lymph nodes resected (metastatic lymph node ratio [MLNR]) predicted papillary thyroid carcinoma (PTC) recurrence, and whether MLNR could alter the predictive ability of TNM nodal classification for recurrence in PTC.MethodsWe conducted a retrospective review of patients with PTC who underwent a total or near‐total thyroidectomy with at least 1 lymph node removed at our institution.ResultsOf 253 patients, 35 (13.8%) developed recurrent disease. The total MLNR (ratio between total metastatic lymph nodes and total number of lymph nodes resected) independently predicted PTC recurrence (odds ratio [OR], 1.024; 95% confidence interval [CI], 1.010–1.039; p = .001). In receiver operating characteristic (ROC) curve analysis, TNM nodal classification with total MLNR had greater accuracy in predicting PTC recurrence than did TNM nodal classification alone (0.726 and 0.675, respectively).ConclusionMLNR is an independent predictor of PTC recurrence and enhances the predictive value of TNM nodal classification. © 2012 Wiley Periodicals, Inc. Head Neck, 2013


  • Yip, Jonathan
  • Orlov, Steven
  • Orlov, David
  • Vaisman, Alon
  • Hernández, Karen Gómez
  • Etarsky, Daniel
  • Kak, Ipshita
  • Parvinnejad, Nikoo
  • Freeman, Jeremy L
  • Walfish, Paul G

publication date

  • April 2013