Complement and the antiphospholipid syndrome

PURPOSE OF REVIEW: The antiphospholipid antibody syndrome (APS) is characterized by arterial or venous thrombosis or pregnancy morbidity in patients with persistent antiphospholipid antibodies (aPL). Experimental data supporting activation of the complement cascade has provided critical insight into the underlying pathophysiology of aPL-induced pregnancy loss and thrombosis. RECENT FINDINGS: Although the mechanism by which pregnancy loss and …