Journal article
In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity
Abstract
Naturally arising CD4(+)CD25(+) regulatory T cells play a pivotal role in the prevention of autoimmunity and in the induction of donor-specific transplantation tolerance. Harnessing regulatory cells for potential adoptive cell therapy is hampered by their lack of antigen-specificity and their limited numbers. Here we describe the generation and expansion of murine CD4(+)CD25(+) T cells with antigen-specificity for an K(d) peptide as potential …
Authors
Tsang J; Jiang S; Tanriver Y; Leung E; Lombardi G; Lechler RI
Journal
International Immunopharmacology, Vol. 6, No. 13-14, pp. 1883–1888
Publisher
Elsevier
Publication Date
12 2006
DOI
10.1016/j.intimp.2006.07.032
ISSN
1567-5769
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntibodiesAntigens, CDAntigens, DifferentiationCD3 ComplexCD4-Positive T-LymphocytesCTLA-4 AntigenCell Culture TechniquesCell LineCoculture TechniquesCytokinesDendritic CellsFlow CytometryForkhead Transcription FactorsGlucocorticoid-Induced TNFR-Related ProteinH-2 AntigensInterleukin-2Interleukin-2 Receptor alpha SubunitIsoantigensL-SelectinLeukocyte Common AntigensLymphocyte ActivationMiceMice, Inbred C57BLPeptide FragmentsReceptors, Antigen, T-Cell, alpha-betaReceptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorT-Lymphocytes, Regulatory