An international trial of antioxidants in the prevention of preeclampsia (INTAPP) Conference Paper uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • OBJECTIVE: We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women. STUDY DESIGN: In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions. RESULTS: Of the 2647 women randomized, 2363 were included in the analysis. There was no difference in the risk of GH and its adverse conditions between groups (relative risk, 0.99; 95% confidence interval, 0.78-1.26). However, vitamins C and E increased the risk of fetal loss or perinatal death (nonprespecified) as well as preterm prelabor rupture of membranes. CONCLUSION: Vitamin C and E supplementation did not reduce the rate of preeclampsia or GH, but increased the risk of fetal loss or perinatal death and preterm prelabor rupture of membranes.

authors

  • Xu, Hairong
  • Perez-Cuevas, Ricardo
  • Xiong, Xu
  • Reyes, Hortensia
  • Roy, Chantal
  • Julien, Pierre
  • Smith, Graeme
  • von Dadelszen, Peter
  • Leduc, Line
  • Audibert, François
  • Moutquin, Jean-Marie
  • Piedboeuf, Bruno
  • Shatenstein, Bryna
  • Parra-Cabrera, Socorro
  • Choquette, Pierre
  • Winsor, Stephanie
  • Wood, Stephen
  • Benjamin, Alice
  • Walker, Mark
  • Helewa, Michael
  • Dubé, Johanne
  • Tawagi, Georges
  • Seaward, Gareth
  • Ohlsson, Arne
  • Magee, Laura A
  • Olatunbosun, Femi
  • Gratton, Robert
  • Shear, Roberta
  • Demianczuk, Nestor
  • Collet, Jean-Paul
  • Wei, Shuqin
  • Fraser, William D

publication date

  • March 2010