Messenger RNAs for neurokinin and histamine receptor subtypes in isolated canine colonic crypts.

Functional subtyping of neurokinin and histamine receptors on the canine proximal colon suggested that different receptors were involved in mediating the neural and non-neural effects on ion transport. If the non-neural effects involved direct stimulation of the transporting epithelial cells, mRNA for specific receptor subtypes should be present in colonic crypt cells. Pharmacological data predicted that RNA from such cells would include mRNAs …