Conference
Inducible MyD88/CD40 (iMC) Costimulation Provides Ligand-Dependent Tumor Eradication By CD123-Specific Chimeric Antigen Receptor T Cells
Abstract
Abstract
Introduction: Promising clinical results with CD19-specific chimeric antigen receptor (CAR)-directed T cells for the treatment of B cell leukemia and lymphoma suggest that CARs may be effective in other hematological malignancies, such as acute myeloid leukemia (AML). CD123/IL-3Rα is an attractive CAR-T cell target due to its high expression on both AML blasts and leukemic stem cells (AML-LSCs). However, the antigen …
Authors
Foster AE; Duong M; Lu A; Chang P; Mahendravada A; Shinners N; Slawin KM; Bayle JH; Spencer DM
Volume
128
Publisher
American Society of Hematology
Publication Date
December 2, 2016
DOI
10.1182/blood.v128.22.4551.4551
Conference proceedings
Blood
Issue
22
ISSN
0006-4971