abstract
- OBJECTIVE: To investigate blood oxygen level-dependent (BOLD) response of human liver to hyperoxic exposure under fasting and postprandial conditions. METHODS: Twelve healthy volunteers and 1 patient with chronic liver disease underwent liver BOLD magnetic resonance imaging at 3.0T. The BOLD images of a single slice were collected (1 image per second) during 3 breathing cycles of hyperoxia (3 minutes, 100% oxygen) with 5 minutes medical air (20.8% oxygen) in both preprandial and postprandial states. The BOLD signal time courses were correlated with a predefined stimulus paradigm. RESULTS: Eight healthy subjects showed increased BOLD signal within 44.6% +/- 21.1% liver area in the fasting state with gas cycling. Two showed slightly reduced BOLD signal within 23.4% +/- 14.9% liver area in the fasting state with gas cycling. In the postprandial state, the degree of change in BOLD signal with gas cycling was reduced for both the subjects having increased and those having decreased signal with gas cycling (13.4% +/- 12.6% positive, 10.9% +/- 10.1% negative; P < 0.05). Chronic liver disease also demonstrated increased BOLD signal with gas cycling, but the correlation decreased postprandially. CONCLUSIONS: The proposed physiological challenges induce certain BOLD signal response patterns in healthy and diseased livers, which may be useful for assessing liver function.