The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14)(p13;q11) translocation. Academic Article uri icon

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abstract

  • Two T-ALL patients carrying a t(11;14)(p13;q11) translocation were analyzed. Southern blotting experiments demonstrated that both patients had rearranged their J delta genes and that the translocation involved the delta locus in both cases. In one patient, cloning, restriction mapping, and sequencing showed that the translocation occurred on a D delta 1-D delta 2-J delta 2 rearranged gene. In addition, the rearrangement on chromosome 11 occurred in both patients within a segment of less than or equal to 2 kb showing the presence in this region of a point of recurrent recombination.

authors

  • Champagne, E
  • Takihara, Y
  • Sagman, U
  • de Sousa, J
  • Burrow, Sarah
  • Lewis, WH
  • Mak, TW
  • Minden, MD

publication date

  • May 1, 1989

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