Gabapentin Does Not Reduce Preoperative Anxiety When Given Prior to Total Hip Arthroplasty Journal Articles uri icon

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  • INTRODUCTION: Gabapentin is an anti-epileptic drug which is also used for the treatment of postoperative pain and a variety of psychiatric diseases including chronic anxiety disorders. We tested the hypothesis that compared with a placebo control, gabapentin would reduce preoperative anxiety in patients undergoing total hip arthroplasty. METHODS: Following ethics approval, patients participating in a larger double blind, randomized, trial of multimodal analgesia were given either gabapentin 600 mg (N = 22) or placebo (N = 48) 2 hours before spinal anesthesia. Prior to administering the study medication, baseline anxiety levels were measured using a visual analog scale (VAS). Two hours after the ingestion of gabapentin or placebo, and prior to surgery, patients again rated their anxiety using a VAS. RESULTS: Anxiety scores did not differ significantly between the groups either before (P = 0.95) or 2 hours after (P = 0.61) ingestion of gabapentin or placebo. Baseline anxiety and postdrug anxiety scores failed to demonstrate a significant association with maximal postoperative pain at rest, maximal postoperative pain with movement, and cumulative morphine consumption 48 hours after surgery. CONCLUSIONS: Administration of gabapentin 600 mg prior to surgery does not reduce preoperative anxiety.


  • Clarke, Hance
  • Kay, Joseph
  • Orser, Beverley A
  • Gollish, Jeffrey
  • Mitsakakis, Nicholas
  • Katz, Joel

publication date

  • June 2010

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