Hepatic steatosis and inflammation: Role of western diet and lipoproteins

Background: We have shown in our previous study in ApoE −/− mice that leukocyte recruitment within the liver precedes the development of steatosis. Our objective was to examine the role of fat and lipoproteins in the development of non‐alcoholic steatohepatitis. Methods: Wild type C57Bl/6 mice fed normal diet (WTND) or a western diet (WTWD), P‐selectin deficient mice fed western diet and LDLr deficient mice fed normal diet (LDLND) were …