Journal article
First-Trimester Screening for Trisomies 21 and 18
Abstract
BACKGROUND: Screening for aneuploid pregnancies is routinely performed after 15 weeks of gestation and has a sensitivity of approximately 65 percent, with a false positive rate of 5 percent. First-trimester markers of aneuploidy have been developed, but their use in combination has not been adequately evaluated in clinical practice.
METHODS: We conducted a multicenter study of screening for trisomies 21 and 18 among patients with pregnancies …
Authors
Wapner R; Thom E; Simpson JL; Pergament E; Silver R; Filkins K; Platt L; Mahoney M; Johnson A; Hogge WA
Journal
The New England Journal of Medicine, Vol. 349, No. 15, pp. 1405–1413
Publisher
Massachusetts Medical Society
Publication Date
October 9, 2003
DOI
10.1056/nejmoa025273
ISSN
0028-4793
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Chorionic Gonadotropin, beta Subunit, HumanChromosomes, Human, Pair 18Down SyndromeFalse Positive ReactionsFemaleFetal DiseasesHumansMaternal AgeNeckPregnancyPregnancy Trimester, FirstPregnancy-Associated Plasma Protein-APrenatal DiagnosisRisk FactorsSensitivity and SpecificityTrisomyUltrasonography, Prenatal