Journal article
Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients
Abstract
The peritoneal membrane becomes damaged in patients on peritoneal dialysis (PD). Gremlin 1 (GREM1) inhibits bone morphogenic proteins (BMPs) and plays a role in kidney development and fibrosis. We evaluated the role of gremlin in peritoneal fibrosis and angiogenesis. In a cohort of 32 stable PD patients, GREM1 concentration in the peritoneal effluent correlated with measures of peritoneal membrane damage. AdGrem1, an adenovirus to overexpress …
Authors
Siddique I; Curran SP; Ghayur A; Liu L; Shi W; Hoff CM; Gangji AS; Brimble KS; Margetts PJ
Journal
American Journal Of Pathology, Vol. 184, No. 11, pp. 2976–2984
Publisher
Elsevier
Publication Date
November 2014
DOI
10.1016/j.ajpath.2014.07.018
ISSN
0002-9440