The effect of glucagon on esophageal peristalsis and clearance

The effect of 0.5 mg intravenous glucagon on esophageal peristalsis and transit of water and barium was studied in nine healthy subjects by concurrent videofluoroscopy and manometry.Glucagon lowered manometric peristaltic amplitude in both mid- and distal esophagus. This reached significance (p=0.0075) in the distal 3 cm of the esophagus 2 min after the injection. The efficiency of esophageal stripping was also reduced (increased proximal escape on fluoroscopy), and became significant (p=0.05) at 2 min after the injection of glucagon.