Journal article
(Sample) Size Matters! An Examination of Sample Size From the SPRINT Trial Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients With Tibial Fractures
Abstract
INTRODUCTION: Inadequate sample size and power in randomized trials can result in misleading findings. This study demonstrates the effect of sample size in a large clinical trial by evaluating the results of the Study to Prospectively evaluate Reamed Intramedullary Nails in Patients with Tibial fractures (SPRINT) trial as it progressed.
METHODS: The SPRINT trial evaluated reamed versus unreamed nailing of the tibia in 1226 patients, and in open …
Authors
Bhandari M; Tornetta P; Rampersad S-A; Sprague S; Heels-Ansdell D; Sanders DW; Schemitsch EH; Swiontkowski M; Walter S
Journal
Journal of Orthopaedic Trauma, Vol. 27, No. 4, pp. 183–188
Publisher
Wolters Kluwer
Publication Date
April 2013
DOI
10.1097/bot.0b013e3182647e0e
ISSN
0890-5339