Journal article
Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms
Abstract
Kynurenic acid (KYNA) is an end stage product of tryptophan metabolism with a variety of functions in the human body, both in the central nervous system (CNS) and in other organs. Although its activity in the human brain has been widely studied and effects on neural cells were emphasized, the effect of KYNA on oligodendroglial cells remains unknown. Present study aims at describing the activity of high concentration of KYNA in OLN-93 cells. The …
Authors
Langner E; Lemieszek MK; Kwiecień JM; Rajtar G; Rzeski W; Turski WA
Journal
Neurochemical Research, Vol. 42, No. 3, pp. 838–845
Publisher
Springer Nature
Publication Date
3 2017
DOI
10.1007/s11064-016-2009-7
ISSN
0364-3190