Journal article
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
Abstract
Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these …
Authors
Szatmari P; Paterson AD; Zwaigenbaum L; Roberts W; Brian J; Liu X-Q; Vincent JB; Skaug JL; Thompson AP; Senman L
Journal
Nature Genetics, Vol. 39, No. 3, pp. 319–328
Publisher
Springer Nature
Publication Date
March 2007
DOI
10.1038/ng1985
ISSN
1061-4036