Journal article
Phase II study of CGP 69846A (ISIS 5132) in recurrent epithelial ovarian cancer: an NCIC clinical trials group study (NCIC IND.116)☆
Abstract
OBJECTIVE: ISIS 5132 is a 20-base phosphorothioate DNA oligonucleotide against human c-raf kinase, a downstream effector of ras oncogene function. C-raf kinase is a molecule in the MAP kinase signaling cascade which is essential for cellular proliferation, the overexpression of which leads to malignant expression. Activity of this compound was documented in a woman with ovarian cancer in a Phase I study.
METHODS: We evaluated ISIS 5132 at a …
Authors
Oza AM; Elit L; Swenerton K; Faught W; Ghatage P; Carey M; McIntosh L; Dorr A; Holmlund JT; Eisenhauer E
Journal
Gynecologic Oncology, Vol. 89, No. 1, pp. 129–133
Publisher
Elsevier
Publication Date
April 2003
DOI
10.1016/s0090-8258(02)00144-0
ISSN
0090-8258