Journal article
The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial
Abstract
Laboratory studies, and one previous uncontrolled trial, have suggested that retinoids may reverse bronchial atypia, a putatively premalignant condition. Sputum sampling is a simple, non-invasive method of assessing atypia. Smokers with at least a 15 pack-year history were screened for sputum atypia. One hundred and fifty subjects' were randomised to receive the synthetic retinoid etretinate 25 mg orally or identical placebo daily for 6 months. …
Authors
Arnold A; Browman G; Levine M; D'Souza T; Johnstone B; Skingley P; Turner-Smith L; Cayco R; Booker L; Newhouse M
Journal
British Journal of Cancer, Vol. 65, No. 5, pp. 737–743
Publisher
Springer Nature
Publication Date
May 1992
DOI
10.1038/bjc.1992.156
ISSN
0007-0920