Journal article
Positive end-expiratory pressure above lower inflection point minimizes influx of activated neutrophils into lung*
Abstract
OBJECTIVES: To compare the effects of low vs. high tidal volume (Vt) with three positive end-expiratory pressure (PEEP) strategies on activated neutrophil influx into the lung.
DESIGN: Prospective, randomized controlled animal study.
Authors
Monkman SL; Andersen CC; Nahmias C; Ghaffer H; Bourgeois JM; Roberts RS; Schmidt B; Kirpalani HM
Journal
Critical Care Medicine, Vol. 32, No. 12, pp. 2471–2475
Publisher
Wolters Kluwer
Publication Date
12 2004
DOI
10.1097/01.ccm.0000147832.13213.1e
ISSN
0090-3493
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnimals, NewbornBiopsy, NeedleCell MovementDisease Models, AnimalFemaleImmunohistochemistryLung ComplianceMaleNeutrophilsPositive-Pressure RespirationPositron-Emission TomographyProbabilityPulmonary VentilationRandom AllocationRespiratory Distress SyndromeSensitivity and SpecificityTidal Volume