Journal article
Fibronectin-Alginate microcapsules improve cell viability and protein secretion of encapsulated Factor IX-engineered human mesenchymal stromal cells
Abstract
Continuous delivery of proteins by engineered cells encapsu-lated in biocompatible polymeric microcapsules is of considerable therapeutic potential. However, this technology has not lived up to expectations due to inadequate cell--matrix interactions and subsequent cell death. In this study we hypoth-esize that the presence of fibronectin in an alginate matrix may enhance the viability and functionality of encapsulated human cord blood-derived …
Authors
Sayyar B; Dodd M; Marquez-Curtis L; Janowska-Wieczorek A; Hortelano G
Journal
Artificial Cells Nanomedicine and Biotechnology, Vol. 43, No. 5, pp. 318–327
Publisher
Taylor & Francis
Publication Date
September 3, 2015
DOI
10.3109/21691401.2014.885446
ISSN
2169-1401