Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post‐thrombotic syndrome Journal Articles uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • BACKGROUND: Post-thrombotic syndrome (PTS) is a frequent chronic complication of deep vein thrombosis (DVT). OBJECTIVE: In the BioSOX study, we investigated whether inflammation markers predict the risk of PTS after DVT. METHODS: We measured C-reactive protein (CRP), ICAM-1, interleukin (IL)-6, and IL-10, at baseline, and 1 month and 6 months after a first proximal DVT, among 803 participants in the SOX trial. Participants were prospectively followed for 24 months for development of PTS. RESULTS: Median CRP levels at 1 month, ICAM-1 levels at baseline, 1 month and 6 months, IL-6 levels at 1 month and 6 months and IL-10 levels at 6 months were higher in patients who developed PTS than in those who did not. Multivariable regression with the median as a cutoff showed risk ratios (RRs) for PTS of 1.23 (95% confidence interval [CI] 1.05-1.45) and 1.25 (95% CI 1.05-1.48) for ICAM-1 at 1 month and 6 months, respectively, and 1.27 (95% CI 1.07-1.51) for IL-10 at 6 months. Quartile-based analysis demonstrated a dose-response association between ICAM-1 and PTS. ICAM-1 and IL-10 were also associated with PTS severity. Analysis of biomarker trajectories after DVT demonstrated an association between the highest-trajectory group of ICAM-1 and PTS. CONCLUSIONS: In this prospective study, ICAM-1 over time was most consistently associated with the risk of PTS. Further study is required to confirm these findings and assess their potential clinical relevance.


  • Rabinovich, A
  • Cohen, JM
  • Cushman, M
  • Wells, PS
  • Rodger, MA
  • Kovacs, MJ
  • Anderson, DR
  • Tagalakis, V
  • Lazo‐Langner, A
  • Solymoss, S
  • Miron, MJ
  • Yeo, E
  • Smith, R
  • Schulman, Sam
  • Kassis, J
  • Kearon, C
  • Chagnon, I
  • Wong, T
  • Demers, C
  • Hanmiah, Rajendar
  • Kaatz, S
  • Selby, R
  • Rathbun, S
  • Desmarais, S
  • Opatrny, L
  • Ortel, TL
  • Ginsberg, JS
  • Kahn, SR

publication date

  • March 2015

has subject area